• Was an Italian painter of the early Renaissance.
• He was active mostly in Perugia and Tuscany.
• Domenico became a pupil of Gentile da Fabriano.
• He is said to have worked with Pisanello in Rome around 1423–1430.
• In a letter from him to Piero di Cosimo de' Medici, dated from Perugia in 1438, where he resided for many years, he mentions his long connection with the fortunes of the Medici family.
• He was a contemporary with Fra Angelico and Fra Filippo Lippi.
• Between 1439 and 1441 he painted a masterpiece of the Adoration of the Magi.
• He influenced Andrea Mantegna.
• He worked at the decorations of the Portinari chapel in the hospital of Santa Maria Nuova in Florence from 1439–1445, and had as his assistants Piero della Francesca and Bicci di Lorenzo.
• His latter days were spent in Florence, where he died on May 15, 1461.
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